Mescaline Abuse: Side Effects, Risks & Treatment

effects of mescaline

For more information on taking peyote safely, see Precautions and Safety and toxicity. The Peyote cactus is a small, bulbous cactus that does not have spines. It grows in clusters that are often referred to as “buttons.” The San Pedro and Peruvian Torch are columnar cacti. Their ribs are thin, yet grow tall and are often found in bunches.

From the earliest recorded time, peyote has been used by natives in northern Mexico and the southwestern United States, where it grows, as a part of traditional religious rites. It has an effect that is similar to LSD or psilocybin (magic mushrooms) and other hallucinogenic drugs. The risk of having negative mental health reactions to hallucinogens is dependent mainly on the existing mental state of the user. As hallucinogens like mescaline can distort reality and heighten emotional states, being in a bad mood or negative mental state can lead to people having bad trips. Going without the drug for any period of time results in painful, distressing physical and psychological symptoms, which, if left uncontrolled, can compel the person to resume the substance abuse.

The resulting intermediate is then oxidized again by a hydroxylase enzyme, likely monophenol hydroxylase again, at carbon 5, and methylated by COMT. The product, methylated at the two meta positions with respect to the alkyl substituent, experiences a final methylation at the 4 carbon by a guaiacol-O-methyltransferase, which also operates by a SAM-dependent mechanism. This barbiturates final methylation step results in the production of mescaline. The information provided on this website does not, and is not intended to, constitute legal or medical advice. All information, content, and materials available on this site are for general educational and informational purposes only. We do not encourage you to break the law or put yourself in harm’s way.

Receptor binding

Unfortunately, precise usage statistics for mescaline aren’t available because surveys tend to lump it together with other substances like LSD, psilocybin, and MDMA. Mescaline could also help reduce suicidal thoughts, according to researchers at the University of Alabama. Using data from the National Survey on Drug Use and Health, the researchers found that people who have used a psychedelic drug at least once in their life show lower rates of suicidal thinking.

  1. Some researchers have found that the antidepressant benefits of mescaline correlate to a subjects’ willingness to engage with the experience, to face themselves and to act upon the insights received.
  2. Mescaline is illegal in the United States, with an exception for specific Native American Church ceremonies.
  3. Beyond cognitive effects, imperceptible doses of mescaline have also been shown to act as anti-inflammatory agents.

A responsible sitter is also a good idea, at least for first-timers. Mescaline should be taken on an empty stomach to minimize nausea and maximize absorption. Mescaline has long been considered a powerful agent for healing and change, making it a central component of the shamanic ceremonies of many indigenous groups in the Americas. For many, a mescaline journey offers deep insight into the self and the universe, giving one a greater sense of connection and spirituality. Mescaline is also known for fostering compassion and gratitude, while also alleviating psychological disorders such as anxiety, depression, PTSD and addiction.

Doing so can have unpredictable effects that may be dangerous, especially if you mix mescaline with other serotonergic drugs like MDMA or cocaine. For that reason, you may want to start with a smaller dose of mescaline, wait an hour to see how you feel, and then take decide whether or not to take the remaining portion of the full dose. Some mescaline powder may be very slightly tan instead of white, which is fine. However, if the powder is yellow or dark tan, or if it burns your tongue when you taste it, it’s a sign that the mescaline was extracted poorly and contains leftover contaminants. Some people also take mescaline as peyote, a small, round, green cactus with a bitter taste, or as a San Pedro cactus, a tall, cylindrical green cactus with fluted ribs. Of course, we cannot generalize current usage statistics from such limited data, but it does give us some idea of its popularity relative to other substances.

How long does Mescaline take to kick in?

Mescaline has also been shown to help people solve problems, access their creativity, be more environmentally conscious, and improve learning. In its original use, the plant medicine was also used to treat a number of ailments, including snake bites, wounds, skin conditions, and general pain. Mescaline is a substituted phenethylamine, a molecule based on the basic phenethylamine structure.

effects of mescaline

Mescaline is a strong mind-altering drug that distorts your visual and auditory perception, as well as your sense of passing time. Avoid operating a vehicle or other heavy machinery while on mescaline. Also keep in mind that at the time of this article’s publication, mescaline is illegal to possess or consume in the United States. Mescaline is the active psychedelic compound in several species of hallucinogenic cacti.

How To Prepare For A Mescaline Trip

If you’re going to buy mescaline, do your due diligence to reduce harm. Avoid purchasing from strangers, and keep in mind that purchasing and possessing any illegal drug could get you into legal trouble. San Pedro cactus is a widespread, fast-growing cactus that grows in the Andes region of South America. It’s also common as a garden or landscape plant in other parts of the world, including the United States. Peyote grows slowly and is becoming vulnerable to overharvesting, partly thanks to increased interest in it as a psychedelic.

Mescaline Safety Tips

When peyote is used in religious ceremonies, it is exempt from its classification as a Schedule I controlled drug under the 1994 American Indian Religious Freedom Act (AIRFA). While there’s no formal research on microdosing mescaline, it is possible. A microdose is usually 10-20% of a full alcohol use disorder and depressive disorders alcohol research dose, which would be milligrams of mescaline. That translates to about 1-2 grams of dried cactus or grams of fresh cactus. Mescaline causes colorful visual distortions, hallucinations, euphoria, and a sense of wellbeing. People usually take it as a dried cactus, a tea, or a pure powder.

You should avoid taking mescaline or any other psychedelic in a setting that you find stressful, or around people you dislike or don’t trust. Set refers to your mindset—your thoughts, mood, and expectations heading into a mescaline trip. Stress, fear, or a controlling mindset may lead to an unpleasant experience (called a “bad trip”). Some people may feel tired or have a slight headache after taking mescaline. However, there are no known serious or lasting physical effects from mescaline and most people experience no hangover symptoms. Some researchers have found that the antidepressant benefits of mescaline correlate to a subjects’ willingness to engage with the experience, to face themselves and to act upon the insights received.

They’re difficult to adulterate, but may be faked (i.e. replaced with a standard cactus cutting that is not psychoactive). San Pedro has a mescaline content similar to that of peyote—around 5% by dry weight. 5 San Pedro is easier to find than peyote and is legal to grow for ornamental purposes (although you can’t legally harvest it for mescaline). Because it’s a natural 12 step programs for addiction recovery product, peyote cactus varies in potency and is a little more difficult to dose than pure mescaline. On the other hand, it’s unlikely to contain contaminants or be cut with other drugs, although some producers may try to pass off another type of non-psychoactive cactus as peyote. Addiction is another promising application for mescaline’s therapeutic potential.

These can lead to people harming themselves or others if they are in a bad place. Mescaline also distorts the user’s perception of the world around them, which can lead to accidents and injury. While combining the two is not known to be physiologically dangerous, psychedelics already have intense and somewhat unpredictable effects when taken alone.

Keep in mind that it is illegal to harvest San Pedro for the purpose of obtaining mescaline. With that in mind, you may want to avoid mescaline if you’re in a negative mental state, a stressful or uncomfortable environment, or around people you don’t like or trust. First and foremost, mescaline is illegal in most places and can come with penalties and incarceration. Aside from legal implications, the risk is almost entirely psychological. This form of mescaline is common in ceremonial practices, especially in South America.

You may also want to avoid obligations, as there’s a good chance you won’t be able to fulfill them while on mescaline, which could give you anxiety. Close your work email, arrange for childcare, and put aside everything that might demand your attention until your session is over. Here’s a look at how mescaline works, as well as its effects, possible benefits, risks, dosage, and more. 25I-NBOMe is an especially risky substance to watch out for with mescaline.

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